(1994) Growth characteristics in fed-batch culture of hybridoma cells with control of glucose and glutamine concentrations. (1993) The effect of the dilution rate on CHO cell physiology and recombinant interferon-gamma production in glucose-limited chemostat culture. (1989) The transient responses of hybridoma cells to nutrient additions in continuous culture: II. IVCC calculated for a specific culture timeframe can be combined with product titers to assess culture productivity trends within specified timeframes of the process or can be used to. IVCC quantifies the effective working time for a dynamic viable cell concentration within a given frame of time, analogous to the calculation of man-hours. (1988) Transient responses of hybridoma metabolism to changes in the oxygen supply rate in continuous culture. The Integral (area under the curve) of Viable Cell Density (IVCD) or Concentration (IVCC) is an essential calculated metric in cell culture operations. (1988) Transient responses of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture. (1991) Kinetic study of hybridoma cell growth in continuous culture. While titer is influenced by the biomass (expressed as IVCD), the culture time and the cell-specifc productivity (qp), we changed independently each of. Increase stability by dampening perturbations of input stream properties 10 David R. Increase productivity for biomass production 2. (1988) A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: effect of nutrient concentration, dilution rate, and pH. Scale-down models are indispensable and crucial tools for process understanding and continuous process improvement in product life-cycle management. To keep the cell concentration higher than the normal steady-state level, cells in the effluent can be recycled back to the reactor. (1988) Mathematical descriptions of hybridoma culture kinetics: I. Integral viable cell concentration (IVCD), understood as the concentration of viable cells that were working during the time the cell culture lasted. The average specific hMab productivity was determined by the slope of the hMab concentration versus the integral of the viable cell density (IVCD) (Fox et. (1998) Mathematical modeling and analysis in biochemical engineering: past accomplishments and future opportunities. (1989) Distinct volume distribution of viable and non-viable hybridoma cells: a flow cytometric study.
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